Games like Osiris Quest
Games like Osiris Quest include SANABI, Katana ZERO, Hollow Knight, Celeste, and Ori and the Will of the Wisps. We matched them by the tags players give Osiris Quest on Steam (Action, 2D Platformer, Platformer, 1990's, and 2D): closest matches first, and among equally close ones the better-known games.

SANABI
Shared: Action · 2D Platformer · Story Rich

Katana ZERO
Shared: Action · Platformer · 2D Platformer

Hollow Knight
Shared: Platformer · 2D · Indie

Celeste
Shared: Platformer · 2D Platformer · Indie

Ori and the Will of the Wisps
Shared: Platformer · Action · Adventure

Pizza Tower
Shared: 2D Platformer · Platformer · Indie

Dust: An Elysian Tail
Shared: Action · Platformer · 2D

Hollow Knight: Silksong
Shared: 2D · Platformer · Indie

Skul: The Hero Slayer
Shared: Action · Indie · 2D

Nine Sols
Shared: Action · Platformer · 2D

F.I.S.T.: Forged In Shadow Torch
Shared: Action · Platformer · 2D Platformer

Super Meat Boy
Shared: Platformer · 2D Platformer · 2D

Owlboy
Shared: Platformer · Adventure · 2D

Mark of the Ninja
Shared: Platformer · Action · 2D

Rogue Legacy 2
Shared: Action · Platformer · Indie

Portal 2
Shared: Platformer · Singleplayer · Story Rich

Tomb Raider Game of the Year
Shared: Action · Adventure · Story Rich

Sonic Origins
Shared: Action · 2D Platformer · Platformer

Gravity Circuit
Shared: Action · Platformer · 2D Platformer

Planet of Lana
Shared: Action · 2D Platformer · Platformer

Deadlight
Shared: Action · Platformer · Indie

God of War
Shared: Action · Story Rich · Adventure

Shovel Knight: Treasure Trove
Shared: Platformer · Action · 2D

Sonic Superstars
Shared: Action · 2D Platformer · Platformer