Games like Orbital Nexus
Games like Orbital Nexus include Dyson Sphere Program, Anno 2205™, Cities: Skylines, Anno 2070™, and Cliff Empire. We matched them by the tags players give Orbital Nexus on Steam (Strategy, Sci-fi, City Builder, Futuristic, and Building): closest matches first, and among equally close ones the better-known games.

Dyson Sphere Program
Shared: Building · Space · Sci-fi

Anno 2205™
Shared: Strategy · City Builder · Sci-fi

Cities: Skylines
Shared: City Builder · Strategy · Building

Anno 2070™
Shared: Strategy · City Builder · Futuristic

Cliff Empire
Shared: Strategy · City Builder · Sci-fi

Jurassic World Evolution
Shared: Strategy · Building · City Builder

Cosmoteer: Starship Architect & Commander
Shared: Sci-fi · Building · Singleplayer

FTL: Faster Than Light
Shared: Strategy · Sci-fi · Space

Planetbase
Shared: City Builder · Strategy · Space

Banished
Shared: Strategy · City Builder · Singleplayer

Oxygen Not Included
Shared: Building · Singleplayer · Resource Management

Frostpunk
Shared: City Builder · Strategy · Resource Management

Jurassic World Evolution 2
Shared: Building · Strategy · City Builder

Cities: Skylines II
Shared: City Builder · Building · Strategy

Hardspace: Shipbreaker
Shared: Sci-fi · Space · Singleplayer

Stellaris
Shared: Strategy · Sci-fi · Space

IXION
Shared: Strategy · City Builder · Space

Spacebase DF-9
Shared: Sci-fi · Strategy · Space

Manor Lords
Shared: Strategy · City Builder · Building

Kerbal Space Program
Shared: Space · Building · Simulation

Against the Storm
Shared: Strategy · City Builder · Building

Foundation
Shared: City Builder · Strategy · Simulation

Tavern Master
Shared: Strategy · Building · City Builder

Space Haven
Shared: Strategy · Space · City Builder