Games like Orbital Defense 2899
Games like Orbital Defense 2899 include FTL: Faster Than Light, Crying Suns, Dungeon Warfare, Infested Planet, and Defense Grid: The Awakening. We matched them by the tags players give Orbital Defense 2899 on Steam (Strategy, Tower Defense, Sci-fi, Pixel Graphics, and Space): closest matches first, and among equally close ones the better-known games.

FTL: Faster Than Light
Shared: Strategy · Sci-fi · Space

Crying Suns
Shared: Strategy · Pixel Graphics · Space

Dungeon Warfare
Shared: Strategy · Tower Defense · Pixel Graphics

Infested Planet
Shared: Strategy · Tower Defense · Sci-fi

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Sci-fi

Dungeon of the ENDLESS™
Shared: Strategy · Tower Defense · Pixel Graphics

Cosmoteer: Starship Architect & Commander
Shared: Sci-fi · Strategy · Space

Creeper World 3: Arc Eternal
Shared: Strategy · Tower Defense · Sci-fi

Stellaris
Shared: Strategy · Space · Sci-fi

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · Tactical

Sid Meier's Civilization®: Beyond Earth™
Shared: Strategy · Sci-fi · Space

Aliens: Dark Descent
Shared: Strategy · Tactical · Sci-fi

Starship Troopers: Terran Command
Shared: Strategy · Sci-fi · Tactical

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · 2D

Heat Signature
Shared: Space · Strategy · Sci-fi

GemCraft - Chasing Shadows
Shared: Strategy · Tower Defense · Indie

XCOM 2
Shared: Strategy · Tactical · Sci-fi

X-Morph: Defense
Shared: Strategy · Tower Defense · Sci-fi

Particle Fleet: Emergence
Shared: Strategy · Space · Sci-fi

Revenge of the Titans
Shared: Strategy · Tower Defense · Sci-fi

XCOM: Enemy Unknown
Shared: Strategy · Sci-fi · Tactical

Kingdom Rush Origins - Tower Defense
Shared: Strategy · Tower Defense · 2D

Into the Breach
Shared: Strategy · Pixel Graphics · Indie

STAR WARS™ Empire at War - Gold Pack
Shared: Strategy · Sci-fi · Space