Games like Opus Magnum
Games like Opus Magnum include SHENZHEN I/O, Baba Is You, Human Resource Machine, SpaceChem, and Infinifactory. We matched them by the tags players give Opus Magnum on Steam (Puzzle, Programming, Automation, Indie, and Simulation): closest matches first, and among equally close ones the better-known games.

SHENZHEN I/O
Shared: Programming · Puzzle · Automation

Baba Is You
Shared: Puzzle · Indie · Logic

Human Resource Machine
Shared: Puzzle · Programming · Indie

SpaceChem
Shared: Puzzle · Programming · Indie

Infinifactory
Shared: Puzzle · Automation · Programming

7 Billion Humans
Shared: Puzzle · Programming · Indie

TIS-100
Shared: Puzzle · Programming · Indie

Papers, Please
Shared: Indie · Simulation · Puzzle

EXAPUNKS
Shared: Puzzle · Programming · Automation

while True: learn()
Shared: Programming · Puzzle · Simulation

Poly Bridge
Shared: Puzzle · Simulation · Singleplayer

The Farmer Was Replaced
Shared: Programming · Automation · Puzzle

Hollow Knight: Silksong
Shared: Indie · Great Soundtrack · Singleplayer

Kaizen: A Factory Story
Shared: Programming · Puzzle · Automation

Hexcells
Shared: Puzzle · Indie · Logic

Poly Bridge 2
Shared: Puzzle · Simulation · Indie

Mini Metro
Shared: Puzzle · Simulation · Indie

Uplink
Shared: Programming · Indie · Simulation

Hacknet
Shared: Programming · Simulation · Singleplayer

OneShot
Shared: Indie · Puzzle · Great Soundtrack

The Signal State
Shared: Puzzle · Automation · Programming

shapez 2 - Factory
Shared: Automation · Puzzle · Simulation

Hollow Knight
Shared: Indie · Great Soundtrack · Singleplayer

World of Goo
Shared: Puzzle · Indie · Singleplayer