Games like One Button Defense
Games like One Button Defense include Cluckmech Oasis, Plants vs. Zombies GOTY Edition, Balatro, FTL: Faster Than Light, and Slots & Daggers. We matched them by the tags players give One Button Defense on Steam (Casual, Strategy, Roguelike, 2D Platformer, and Top-Down Shooter): closest matches first, and among equally close ones the better-known games.

Cluckmech Oasis
Shared: Strategy · Roguelike · Top-Down Shooter

Plants vs. Zombies GOTY Edition
Shared: Strategy · Casual · 2D

Balatro
Shared: Roguelike · Strategy · Casual

FTL: Faster Than Light
Shared: Roguelike · Strategy · Indie

Slots & Daggers
Shared: Casual · Strategy · Roguelike

Plague Inc: Evolved
Shared: Strategy · Casual · Indie

RACCOIN: Coin Pusher Roguelike
Shared: Strategy · Roguelike · Casual

Game Dev Tycoon
Shared: Strategy · Casual · Indie

Ballionaire
Shared: Casual · Roguelike · Strategy

Zup! S
Shared: Casual · Indie · 2D

Nubby's Number Factory
Shared: Strategy · Roguelike · Indie

Bloons TD 6
Shared: Strategy · Casual · Singleplayer

Stoneshard
Shared: Roguelike · Strategy · 2D

Vampire Survivors
Shared: Casual · Roguelike · Indie

Slay the Spire 2
Shared: Roguelike · Strategy · Indie

Apocalypse Party
Shared: Casual · Top-Down Shooter · Roguelike

911 Operator
Shared: Strategy · Casual · Indie

Home Behind
Shared: Casual · Strategy · Indie

Town of Salem
Shared: Strategy · Casual · Indie

Rain World
Shared: Indie · Atmospheric · 2D

Mini Motorways
Shared: Strategy · Casual · Indie

The Binding of Isaac: Rebirth
Shared: Roguelike · Indie · 2D

Brotato
Shared: Roguelike · Singleplayer · Indie

A Game About Feeding A Black Hole
Shared: Casual · Strategy · Indie