Games like Once Upon The Universe
Games like Once Upon The Universe include Kerbal Space Program, WorldBox - God Simulator, Universe Sandbox, X4: Foundations, and Stellaris. We matched them by the tags players give Once Upon The Universe on Steam (God Game, Space Sim, Sandbox, Life Sim, and Space): closest matches first, and among equally close ones the better-known games.

Kerbal Space Program
Shared: Sandbox · Space · Space Sim

WorldBox - God Simulator
Shared: God Game · Sandbox · Simulation

Universe Sandbox
Shared: Sandbox · Space Sim · Space

X4: Foundations
Shared: Space Sim · Space · Sandbox

Stellaris
Shared: Space · Strategy · Sandbox

Hardspace: Shipbreaker
Shared: Space · Sandbox · Simulation

SPORE™
Shared: God Game · Sandbox · Space

Stardew Valley
Shared: Life Sim · Pixel Graphics · Sandbox

FTL: Faster Than Light
Shared: Space · Strategy · Sci-fi

Elite Dangerous
Shared: Space Sim · Space · Simulation

Dyson Sphere Program
Shared: Space · Sandbox · Simulation

Spaceflight Simulator
Shared: Space Sim · Sandbox · Space

X Rebirth
Shared: Space Sim · Space · Simulation

Space Engineers
Shared: Sandbox · Space · Simulation

Cosmoteer: Starship Architect & Commander
Shared: Space · Space Sim · Sci-fi

X3: Terran Conflict
Shared: Sandbox · Space · Space Sim

Totally Accurate Battle Simulator
Shared: Sandbox · Simulation · Strategy

Universe Sandbox
Shared: Sandbox · Space · Simulation

Starpoint Gemini Warlords
Shared: Space · Space Sim · Strategy

SpaceEngine
Shared: Sandbox · Space Sim · Space

Kerbal Space Program 2
Shared: Sandbox · Space · Space Sim

Reus
Shared: God Game · Strategy · Sandbox

The Universim
Shared: God Game · Sandbox · Space

SPORE™ Galactic Adventures
Shared: Space · Simulation · Sandbox