Games like NucleoSynthetica
Games like NucleoSynthetica include Factorio, Kerbal Space Program, Dyson Sphere Program, Satisfactory, and Cookie Clicker. We matched them by the tags players give NucleoSynthetica on Steam (Idler, Incremental, Crafting, Sandbox, and Automation): closest matches first, and among equally close ones the better-known games.

Factorio
Shared: Automation · Sandbox · Crafting

Kerbal Space Program
Shared: Sandbox · Space · Simulation

Dyson Sphere Program
Shared: Automation · Space · Simulation

Satisfactory
Shared: Crafting · Automation · Sandbox

Cookie Clicker
Shared: Idler · Incremental · Casual

Cell to Singularity - Evolution Never Ends
Shared: Incremental · Idler · Simulation

shapez
Shared: Automation · Sandbox · Crafting

Spaceflight Simulator
Shared: Sandbox · Space · Simulation

Kerbal Space Program 2
Shared: Sandbox · Space · Exploration

Outpath
Shared: Crafting · Automation · Sandbox

Fortune Mill
Shared: Idler · Incremental · Automation

shapez 2 - Factory
Shared: Automation · Sandbox · Crafting

Sixty Four
Shared: Incremental · Automation · Simulation

Stationeers
Shared: Automation · Sandbox · Crafting

Potion Craft: Alchemist Simulator
Shared: Crafting · Simulation · Sandbox

Shelldiver
Shared: Incremental · Idler · Resource Management

Oxygen Not Included
Shared: Sandbox · Resource Management · Simulation

The Last Caretaker
Shared: Crafting · Automation · Sandbox

Space Engineers
Shared: Sandbox · Space · Simulation

Plantera
Shared: Idler · Incremental · Sandbox

Forage Wizard
Shared: Crafting · Incremental · Simulation

Beltmatic
Shared: Automation · Sandbox · Idler

MineMogul
Shared: Automation · Crafting · Simulation

Starbound
Shared: Sandbox · Crafting · Space