Games like Nexus Defenders
Games like Nexus Defenders include Shadow Tactics: Blades of the Shogun, Defense Grid: The Awakening, Creeper World 3: Arc Eternal, Creeper World 4, and Bloons TD 6. We matched them by the tags players give Nexus Defenders on Steam (Tower Defense, Real Time Tactics, Strategy, PvE, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Shadow Tactics: Blades of the Shogun
Shared: Strategy · Real Time Tactics · Singleplayer

Defense Grid: The Awakening
Shared: Tower Defense · Strategy · Singleplayer

Creeper World 3: Arc Eternal
Shared: Tower Defense · Strategy · Indie

Creeper World 4
Shared: Tower Defense · Real Time Tactics · Strategy

Bloons TD 6
Shared: Tower Defense · Strategy · Singleplayer

Aliens: Dark Descent
Shared: Strategy · Real Time Tactics · Singleplayer

Taur
Shared: Tower Defense · Strategy · Indie

Company of Heroes 3
Shared: Strategy · Singleplayer · RTS

Call to Arms - Gates of Hell: Ostfront
Shared: Real Time Tactics · Strategy · Singleplayer

Infested Planet
Shared: Tower Defense · Strategy · Singleplayer

Age of Mythology: Retold
Shared: Strategy · RTS · Singleplayer

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

Planetary Annihilation: TITANS
Shared: Real Time Tactics · Strategy · RTS

Desperados III
Shared: Real Time Tactics · Strategy · Singleplayer

Element TD 2 - Tower Defense
Shared: Tower Defense · Real Time Tactics · Strategy

Shadowrun Returns
Shared: Strategy · Isometric · Indie

Anomaly Warzone Earth
Shared: Tower Defense · Strategy · Indie

Axon TD: Uprising - Tower Defense
Shared: Tower Defense · Real Time Tactics · Strategy

X-Morph: Defense
Shared: Tower Defense · Strategy · Indie

GemCraft - Chasing Shadows
Shared: Tower Defense · Strategy · Singleplayer

Mindustry
Shared: Tower Defense · Strategy · RTS

Age of Darkness: Final Stand
Shared: Tower Defense · Strategy · PvE

Starship Troopers: Terran Command
Shared: Strategy · Singleplayer · RTS

Orcs Must Die! 3
Shared: Tower Defense · Strategy · PvE