Games like Mystic Tesserae
Games like Mystic Tesserae include People Playground, Stardew Valley, The Escapists, Graveyard Keeper, and DAVE THE DIVER. We matched them by the tags players give Mystic Tesserae on Steam (Simulation, 2D, Pixel Graphics, Automation, and Crafting): closest matches first, and among equally close ones the better-known games.

People Playground
Shared: 2D · Physics · Simulation

Stardew Valley
Shared: Pixel Graphics · Simulation · Crafting

The Escapists
Shared: Pixel Graphics · 2D · Simulation

Graveyard Keeper
Shared: Pixel Graphics · Simulation · Crafting

DAVE THE DIVER
Shared: Pixel Graphics · Casual · Simulation

Potion Craft: Alchemist Simulator
Shared: Simulation · Crafting · Singleplayer

Factorio
Shared: Automation · Crafting · 2D

Papers, Please
Shared: Simulation · Pixel Graphics · Singleplayer

Maltese's Fluffy Onsen
Shared: Simulation · Pixel Graphics · Automation

The Escapists 2
Shared: Pixel Graphics · 2D · Simulation

Noita
Shared: Pixel Graphics · Physics · 2D

Touhou Mystia's Izakaya
Shared: Simulation · Pixel Graphics · Casual

Terraria
Shared: 2D · Pixel Graphics · Crafting

shapez
Shared: Automation · Crafting · Singleplayer

Sand:box
Shared: Simulation · Pixel Graphics · 2D

Vampire Survivors
Shared: Pixel Graphics · 2D · Singleplayer

Garry's Mod
Shared: Physics · Simulation · Casual

Game Dev Tycoon
Shared: Simulation · 2D · Singleplayer

Fortune Mill
Shared: Pixel Graphics · Automation · Simulation

Forager
Shared: Pixel Graphics · Crafting · 2D

Cooking Simulator
Shared: Simulation · Singleplayer · Physics

Spaceflight Simulator
Shared: Simulation · 2D · Singleplayer

Bridge Constructor Portal
Shared: Simulation · 2D · Physics

Click Mage
Shared: Simulation · Pixel Graphics · Casual