Games like Mystic Defense
Games like Mystic Defense include Rock 'N' Roll Defense, There Is No Game: Wrong Dimension, Kingdom Rush - Tower Defense, Timberman, and Bloons TD 5. We matched them by the tags players give Mystic Defense on Steam (Casual, Action, Indie, Tower Defense, and Point & Click): closest matches first, and among equally close ones the better-known games.

Rock 'N' Roll Defense
Shared: Casual · Tower Defense · Action

There Is No Game: Wrong Dimension
Shared: Indie · Point & Click · Casual

Kingdom Rush - Tower Defense
Shared: Tower Defense · Casual · Action

Timberman
Shared: Casual · Indie · Action

Bloons TD 5
Shared: Tower Defense · Action · Casual

Witch It
Shared: Casual · Indie · Action

Monument Valley 2
Shared: Casual · Action · Point & Click

Orcs Must Die! 2
Shared: Action · Tower Defense · Indie

CastleStorm
Shared: Indie · Action · Tower Defense

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Casual · Indie

Dead Bits
Shared: Action · Casual · Indie

Gensokyo Night Festival
Shared: Action · Indie · Casual

Zup! 2
Shared: Casual · Indie · Point & Click

Pikuniku
Shared: Casual · Indie · Action

Gang Beasts
Shared: Action · Casual · Indie

One Finger Death Punch 2
Shared: Action · Indie · Casual

Bardbarian
Shared: Indie · Casual · Tower Defense

Timberman VS
Shared: Casual · Action · Indie

Retrowave
Shared: Indie · Casual · Action

Zup!
Shared: Casual · Indie · Point & Click

Superflight
Shared: Indie · Casual · Action

Rock of Ages
Shared: Indie · Action · Tower Defense

Cyberhunt
Shared: Action · Casual · Indie

Orcs Must Die!
Shared: Action · Tower Defense · Indie