Games like Mysteryville 2
Games like Mysteryville 2 include The Room, The Room 4: Old Sins, Enigmatis: The Ghosts of Maple Creek, The Room Two, and Boxes: Lost Fragments. We matched them by the tags players give Mysteryville 2 on Steam (Casual, Adventure, Hidden Object, Detective, and Puzzle): closest matches first, and among equally close ones the better-known games.

The Room
Shared: Puzzle · Adventure · Point & Click

The Room 4: Old Sins
Shared: Adventure · Puzzle · Point & Click

Enigmatis: The Ghosts of Maple Creek
Shared: Adventure · Hidden Object · Casual

The Room Two
Shared: Puzzle · Hidden Object · Point & Click

Boxes: Lost Fragments
Shared: Adventure · Casual · Puzzle

Duck Detective: The Secret Salami
Shared: Casual · Detective · Adventure

Enigmatis 3: The Shadow of Karkhala
Shared: Casual · Hidden Object · Adventure

The House of Da Vinci
Shared: Hidden Object · Puzzle · Point & Click

Morphopolis
Shared: Hidden Object · Casual · Puzzle

The Roottrees are Dead
Shared: Detective · Puzzle · Point & Click

Chants of Sennaar
Shared: Adventure · Puzzle · Point & Click

Enigmatis 2: The Mists of Ravenwood
Shared: Adventure · Hidden Object · Casual

Sherlock Holmes: The Devil's Daughter
Shared: Adventure · Detective · Puzzle

Sherlock Holmes: Crimes and Punishments
Shared: Adventure · Detective · Puzzle

9 Clues: The Secret of Serpent Creek
Shared: Casual · Hidden Object · Adventure

The Room Three
Shared: Adventure · Puzzle · Point & Click

Strange Horticulture
Shared: Puzzle · Detective · Mystery

Murders on the Yangtze River
Shared: Adventure · Detective · Puzzle

The Case of the Golden Idol
Shared: Detective · Puzzle · Mystery

Nancy Drew®: Midnight in Salem
Shared: Adventure · Detective · Casual

The Rewinder
Shared: Adventure · Puzzle · Detective

Syberia
Shared: Adventure · Casual · Puzzle

Hidden Folks
Shared: Casual · Hidden Object · Puzzle

Sherlock Holmes and The Hound of The Baskervilles
Shared: Casual · Adventure · Hidden Object