Games like Mystery Island:Missing Amy
Games like Mystery Island:Missing Amy include No Case Should Remain Unsolved, The Case of the Golden Idol, Chants of Sennaar, Phoenix Wright: Ace Attorney Trilogy, and Tangle Tower. We matched them by the tags players give Mystery Island:Missing Amy on Steam (Point & Click, Puzzle, Adventure, 2D, and Mystery): closest matches first, and among equally close ones the better-known games.

No Case Should Remain Unsolved
Shared: Puzzle · Point & Click · Investigation

The Case of the Golden Idol
Shared: Puzzle · Mystery · Point & Click

Chants of Sennaar
Shared: Puzzle · Adventure · Point & Click

Phoenix Wright: Ace Attorney Trilogy
Shared: Visual Novel · Mystery · Detective

Tangle Tower
Shared: Point & Click · Puzzle · Visual Novel

Strange Horticulture
Shared: Puzzle · Mystery · Point & Click

The Mermaid Mask
Shared: Point & Click · Adventure · Puzzle

Murders on the Yangtze River
Shared: Puzzle · Adventure · Mystery

Sanfu
Shared: Puzzle · Mystery · 2D

The Roottrees are Dead
Shared: Puzzle · Point & Click · Mystery

The Rise of the Golden Idol
Shared: Mystery · Puzzle · Adventure

Storyteller
Shared: Point & Click · Puzzle · 2D

The Room
Shared: Puzzle · Point & Click · Mystery

Desktop Explorer
Shared: Point & Click · Puzzle · Investigation

Her Story
Shared: Puzzle · Investigation · Interactive Fiction

The Room 4: Old Sins
Shared: Puzzle · Point & Click · Adventure

Lay a Beauty to Rest: The Darkness Peach Blossom Spring
Shared: Adventure · Visual Novel · Mystery

The House of Da Vinci
Shared: Puzzle · Point & Click · Mystery

Detective Grimoire
Shared: Point & Click · Puzzle · 2D

The White Door
Shared: Puzzle · Adventure · Point & Click

The Room Two
Shared: Puzzle · Point & Click · Mystery

The Rewinder
Shared: Adventure · Puzzle · Mystery

Danganronpa: Trigger Happy Havoc
Shared: Visual Novel · Mystery · Detective

The Room Three
Shared: Puzzle · Point & Click · Adventure