Games like Myst: Masterpiece Edition
Games like Myst: Masterpiece Edition include The Room, The Room 4: Old Sins, Firewatch, Riven (1997), and Syberia. We matched them by the tags players give Myst: Masterpiece Edition on Steam (Adventure, Casual, Point & Click, Puzzle, and Classic): closest matches first, and among equally close ones the better-known games.

The Room
Shared: Puzzle · Point & Click · Adventure

The Room 4: Old Sins
Shared: Adventure · Puzzle · Point & Click

Firewatch
Shared: Adventure · Atmospheric · Mystery

Riven (1997)
Shared: Adventure · Point & Click · Puzzle

Syberia
Shared: Adventure · Point & Click · Puzzle

Outer Wilds
Shared: Adventure · Exploration · Puzzle

What Remains of Edith Finch
Shared: Atmospheric · Adventure · Mystery

The Room Two
Shared: Puzzle · Point & Click · Adventure

The Room Three
Shared: Adventure · Puzzle · Point & Click

realMyst: Masterpiece Edition
Shared: Adventure · Point & Click · Puzzle

Quern - Undying Thoughts
Shared: Adventure · Puzzle · Atmospheric

Machinarium
Shared: Point & Click · Puzzle · Adventure

Obduction
Shared: Adventure · Puzzle · Exploration

Boxes: Lost Fragments
Shared: Adventure · Puzzle · Point & Click

The House of Da Vinci
Shared: Puzzle · Point & Click · Adventure

Chants of Sennaar
Shared: Adventure · Puzzle · Point & Click

Riven
Shared: Adventure · Puzzle · Exploration

Call of the Sea
Shared: Adventure · Puzzle · Atmospheric

Grim Fandango Remastered
Shared: Adventure · Point & Click · Classic

Gorogoa
Shared: Puzzle · Casual · Point & Click

Servant of the Lake
Shared: Adventure · Puzzle · Point & Click

Spirit of the North
Shared: Adventure · Casual · Atmospheric

Syberia: The World Before
Shared: Adventure · Point & Click · Puzzle

Amanda the Adventurer
Shared: Puzzle · Adventure · 1990's