Games like Myriad Mayhem
Games like Myriad Mayhem include Grim Dawn, Wolcen: Lords of Mayhem, Path of Exile, Path of Exile 2, and Hades. We matched them by the tags players give Myriad Mayhem on Steam (Roguelite, Base Building, Hack and Slash, Strategy, and Character Customization): closest matches first, and among equally close ones the better-known games.

Grim Dawn
Shared: Hack and Slash · Dark Fantasy · Action RPG

Wolcen: Lords of Mayhem
Shared: Hack and Slash · Action RPG · Singleplayer

Path of Exile
Shared: Hack and Slash · Dark Fantasy · Action RPG

Path of Exile 2
Shared: Hack and Slash · Action RPG · Dark Fantasy

Hades
Shared: Roguelite · Hack and Slash · Singleplayer

Cult of the Lamb
Shared: Base Building · Roguelite · Character Customization

Death Must Die
Shared: Roguelite · Hack and Slash · Pixel Graphics

Halls of Torment
Shared: Roguelite · Dark Fantasy · Hack and Slash

The Riftbreaker
Shared: Base Building · Hack and Slash · Survival

Hades II
Shared: Roguelite · Hack and Slash · Action

Diablo® IV
Shared: Hack and Slash · Action RPG · Loot

Last Epoch
Shared: Hack and Slash · Action RPG · Loot

This War of Mine
Shared: Strategy · Survival · Base Building

Black Myth: Wukong
Shared: Action RPG · Action · Dark Fantasy

Everything is Crab: The Animal Evolution Roguelite
Shared: Roguelite · Character Customization · Strategy

Megabonk
Shared: Roguelite · Survival · Singleplayer

Witchfire
Shared: Roguelite · Dark Fantasy · RPG

ARK: Survival Ascended
Shared: Base Building · Survival · Character Customization

RimWorld
Shared: Base Building · Strategy · Survival

Diablo II: Resurrected – Infernal Edition
Shared: Hack and Slash · Strategy · Action RPG

Enshrouded
Shared: Base Building · Survival · RPG

We Who Are About To Die
Shared: Roguelite · Strategy · Action

Sands of Salzaar
Shared: Strategy · Hack and Slash · Character Customization

Warhammer: Vermintide 2
Shared: Hack and Slash · Dark Fantasy · Roguelite