Games like My Wifey
Games like My Wifey include Sweet Home, Unpacking, Date Everything!, Celeste, and Fields of Mistria. We matched them by the tags players give My Wifey on Steam (Simulation, Female Protagonist, LGBTQ+, Dating Sim, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Sweet Home
Shared: Female Protagonist · LGBTQ+ · Dating Sim

Unpacking
Shared: Simulation · Pixel Graphics · Cute

Date Everything!
Shared: LGBTQ+ · Dating Sim · Simulation

Celeste
Shared: Female Protagonist · Pixel Graphics · Singleplayer

Fields of Mistria
Shared: Dating Sim · Simulation · Pixel Graphics

Love Curse: Find Your Soulmate
Shared: Female Protagonist · LGBTQ+ · Dating Sim

Volcano Princess
Shared: Female Protagonist · Simulation · Dating Sim

鬼谷八荒 Tale of Immortal
Shared: Simulation · Singleplayer · Dating Sim

The Sims™ 4
Shared: Simulation · Singleplayer · Dating Sim

Slime Rancher 2
Shared: Singleplayer · Simulation · Cute

Kitty Powers' Matchmaker
Shared: Dating Sim · LGBTQ+ · Simulation

STORY OF SEASONS: Friends of Mineral Town
Shared: Simulation · Dating Sim · Singleplayer

Potion Permit
Shared: Singleplayer · Dating Sim · Colorful

Slime Rancher
Shared: Singleplayer · Simulation · Cute

Sticky Business
Shared: Simulation · LGBTQ+ · Cute

Shelldiver
Shared: Incremental · Simulation · 2D

Dream Daddy: A Dad Dating Simulator
Shared: LGBTQ+ · Dating Sim · Simulation

Papers, Please
Shared: Simulation · Singleplayer · Pixel Graphics

Muse Dash
Shared: Female Protagonist · Singleplayer · Cute

Stardew Valley
Shared: Simulation · Pixel Graphics · Singleplayer

1 to 1 humanoid edible toys
Shared: Female Protagonist · LGBTQ+ · Dating Sim

Unfair Flips
Shared: Simulation · Incremental · 2D

Paralives
Shared: Simulation · LGBTQ+ · Singleplayer

Calico
Shared: LGBTQ+ · Simulation · Cute