Games like My First Ant Farm
Games like My First Ant Farm include SPORE™, Stardew Valley, RimWorld, Prison Architect, and Oxygen Not Included. We matched them by the tags players give My First Ant Farm on Steam (Idler, Casual, Colony Sim, Simulation, and Sandbox): closest matches first, and among equally close ones the better-known games.

SPORE™
Shared: Colony Sim · Sandbox · Simulation

Stardew Valley
Shared: Farming Sim · Simulation · Sandbox

RimWorld
Shared: Colony Sim · Sandbox · Simulation

Prison Architect
Shared: Simulation · Colony Sim · Sandbox

Oxygen Not Included
Shared: Colony Sim · Sandbox · Simulation

Garry's Mod
Shared: Sandbox · Casual · Simulation

MyVoiceZoo
Shared: Casual · Simulation · Idler

People Playground
Shared: Sandbox · Simulation · 2D

Universe Sandbox
Shared: Simulation · Sandbox · Science

Game Dev Tycoon
Shared: Simulation · Casual · 2D

Cities: Skylines
Shared: Simulation · Sandbox · Singleplayer

Potion Craft: Alchemist Simulator
Shared: Simulation · Casual · Singleplayer

Nodebuster
Shared: Casual · Idler · Simulation

Train Simulator Classic
Shared: Simulation · Casual · Realistic

Cities: Skylines II
Shared: Simulation · Sandbox · Singleplayer

I Am Future: Cozy Apocalypse Survival
Shared: Casual · Simulation · Farming Sim

Kerbal Space Program
Shared: Simulation · Sandbox · Science

Cookie Clicker
Shared: Idler · Casual · 2D

The Sims™ 4
Shared: Simulation · Sandbox · Casual

Tiny Pasture
Shared: Idler · Casual · Farming Sim

Totally Accurate Battle Simulator
Shared: Simulation · Sandbox · Realistic

Spaceflight Simulator
Shared: Sandbox · Simulation · 2D

SpaceEngine
Shared: Casual · Sandbox · Science

Maltese's Fluffy Onsen
Shared: Simulation · Casual · Idler