Games like My Big Sister
Games like My Big Sister include DISTRAINT: Deluxe Edition, OMORI, Sally Face - Episode One, OneShot, and Fran Bow. We matched them by the tags players give My Big Sister on Steam (Indie, Adventure, Pixel Graphics, Story Rich, and Horror): closest matches first, and among equally close ones the better-known games.

DISTRAINT: Deluxe Edition
Shared: Indie · Pixel Graphics · Horror

OMORI
Shared: Indie · Story Rich · Pixel Graphics

Sally Face - Episode One
Shared: Indie · Story Rich · Psychological Horror

OneShot
Shared: Indie · Pixel Graphics · Story Rich

Fran Bow
Shared: Story Rich · Psychological Horror · Adventure

Little Nightmares
Shared: Adventure · Horror · Indie

Mouthwashing
Shared: Story Rich · Horror · Indie

Tiny Bunny
Shared: Story Rich · Horror · Psychological Horror

FAITH: The Unholy Trinity
Shared: Pixel Graphics · Indie · Horror

Little Nightmares II
Shared: Adventure · Horror · Story Rich

Tales of the Black Forest
Shared: Pixel Graphics · Indie · Adventure

SOMA
Shared: Horror · Story Rich · Psychological Horror

The Witch's House MV
Shared: Pixel Graphics · Indie · Horror

No, I'm not a Human
Shared: Indie · Horror · Psychological Horror

Mad Father
Shared: Horror · Pixel Graphics · Psychological Horror

Impostor Factory
Shared: Story Rich · Pixel Graphics · Adventure

DISTRAINT 2
Shared: Story Rich · Horror · Psychological Horror

Detention
Shared: Indie · Horror · Psychological Horror

Outlast
Shared: Horror · Psychological Horror · Atmospheric

Little Misfortune
Shared: Indie · Psychological Horror · Story Rich

To the Moon
Shared: Indie · Story Rich · Pixel Graphics

Layers of Fear (2016)
Shared: Horror · Psychological Horror · Indie

Firewatch
Shared: Adventure · Story Rich · Atmospheric

CARRION
Shared: Pixel Graphics · Indie · Horror