Games like Mos Speedrun 2
Games like Mos Speedrun 2 include Broforce, Katana ZERO, Skul: The Hero Slayer, Rogue Legacy 2, and Rogue Legacy. We matched them by the tags players give Mos Speedrun 2 on Steam (Action, Indie, Platformer, Arcade, and Pixel Graphics): closest matches first, and among equally close ones the better-known games.

Broforce
Shared: Action · Pixel Graphics · Platformer

Katana ZERO
Shared: Action · Pixel Graphics · Platformer

Skul: The Hero Slayer
Shared: Action · Indie · Pixel Graphics

Rogue Legacy 2
Shared: Action · Arcade · Platformer

Rogue Legacy
Shared: Platformer · Indie · Action

Shovel Knight: Treasure Trove
Shared: Platformer · Indie · Pixel Graphics

Downwell
Shared: Indie · Pixel Graphics · Platformer

Risk of Rain (2013)
Shared: Indie · Action · Platformer

UFO 50
Shared: Indie · Action · Pixel Graphics

SANABI
Shared: Action · Pixel Graphics · Indie

Rivals of Aether
Shared: Indie · Pixel Graphics · Platformer

Celeste
Shared: Indie · Pixel Graphics · Platformer

Vampire Survivors
Shared: Pixel Graphics · Indie · Action

Out There Somewhere
Shared: Platformer · Indie · Pixel Graphics

BlazBlue Entropy Effect
Shared: Action · Platformer · Pixel Graphics

Pizza Tower
Shared: Indie · Platformer · Pixel Graphics

Hotline Miami
Shared: Action · Indie · Pixel Graphics

Axiom Verge
Shared: Indie · Platformer · Action

Gravity Circuit
Shared: Action · Indie · Platformer

UBERMOSH
Shared: Action · Indie · Pixel Graphics

MO:Astray
Shared: Action · Indie · Pixel Graphics

Super Meat Boy
Shared: Platformer · Indie · Pixel Graphics

TowerFall Ascension
Shared: Indie · Action · Platformer

Exit the Gungeon
Shared: Indie · Action · Arcade