Games like MOLEK-SYNTEZ
Games like MOLEK-SYNTEZ include Opus Magnum, while True: learn(), Human Resource Machine, TIS-100, and SHENZHEN I/O. We matched them by the tags players give MOLEK-SYNTEZ on Steam (Simulation, Puzzle, Programming, Indie, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Opus Magnum
Shared: Puzzle · Programming · Simulation

while True: learn()
Shared: Simulation · Programming · Puzzle

Human Resource Machine
Shared: Puzzle · Programming · Indie

TIS-100
Shared: Puzzle · Programming · Simulation

SHENZHEN I/O
Shared: Programming · Puzzle · Simulation

SpaceChem
Shared: Puzzle · Programming · Indie

7 Billion Humans
Shared: Puzzle · Programming · Simulation

The Farmer Was Replaced
Shared: Programming · Puzzle · Automation

EXAPUNKS
Shared: Puzzle · Programming · Simulation

Baba Is You
Shared: Puzzle · Indie · Singleplayer

Papers, Please
Shared: Simulation · Indie · Singleplayer

Infinifactory
Shared: Puzzle · Indie · Programming

Uplink
Shared: Simulation · Programming · Indie

The Signal State
Shared: Puzzle · Simulation · Programming

Kaizen: A Factory Story
Shared: Programming · Puzzle · Simulation

Cyber Manhunt
Shared: Simulation · Puzzle · Indie

Kerbal Space Program
Shared: Simulation · Science · Indie

Poly Bridge
Shared: Simulation · Puzzle · Singleplayer

Mini Metro
Shared: Puzzle · Simulation · Indie

Word Factori
Shared: Puzzle · Programming · Simulation

Mini Motorways
Shared: Simulation · Puzzle · Indie

Automachef
Shared: Simulation · Puzzle · Indie

Autonauts
Shared: Simulation · Programming · Indie

JOY OF PROGRAMMING - Software Engineering Simulator
Shared: Programming · Puzzle · Automation