Games like Molecoole
Games like Molecoole include The Binding of Isaac: Rebirth, Vampire Survivors, The Binding of Isaac, Spelunky, and Skul: The Hero Slayer. We matched them by the tags players give Molecoole on Steam (Action Roguelike, Difficult, Singleplayer, Arcade, and 2D): closest matches first, and among equally close ones the better-known games.

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Difficult · Singleplayer

Vampire Survivors
Shared: Action Roguelike · 2D · Singleplayer

The Binding of Isaac
Shared: Action Roguelike · Difficult · Procedural Generation

Spelunky
Shared: Action Roguelike · Difficult · 2D

Skul: The Hero Slayer
Shared: Action Roguelike · Action · 2D

A Dance of Fire and Ice
Shared: Difficult · Singleplayer · 2D

Geometry Dash
Shared: Difficult · 2D · Singleplayer

Rogue Legacy 2
Shared: Arcade · Difficult · Action

Enter the Gungeon
Shared: Action Roguelike · Difficult · Roguelike

Hades
Shared: Action Roguelike · Singleplayer · Action

Rogue Legacy
Shared: Action Roguelike · Singleplayer · 2D

Have a Nice Death
Shared: Action Roguelike · Singleplayer · 2D

Megabonk
Shared: Action Roguelike · Singleplayer · Roguelike

Nuclear Throne
Shared: Action Roguelike · Difficult · Roguelike

Dungreed
Shared: Action Roguelike · 2D · Singleplayer

Dead Cells
Shared: Action Roguelike · 2D · Roguelike

Risk of Rain (2013)
Shared: Action Roguelike · Difficult · Roguelike

BALL x PIT
Shared: Arcade · Action Roguelike · Action

Downwell
Shared: Action Roguelike · Arcade · Difficult

Super Hexagon
Shared: Difficult · Arcade · Singleplayer

Risk of Rain 2
Shared: Action Roguelike · Action · Roguelike

Post Void
Shared: Action Roguelike · Difficult · Singleplayer

Brotato
Shared: Singleplayer · Action Roguelike · Roguelike

Hollow Knight: Silksong
Shared: Difficult · Singleplayer · 2D