Games like Microtopia: Prologue
Games like Microtopia: Prologue include Factorio, Satisfactory, Oxygen Not Included, RimWorld, and Prison Architect. We matched them by the tags players give Microtopia: Prologue on Steam (Automation, Colony Sim, Base Building, Resource Management, and Sandbox): closest matches first, and among equally close ones the better-known games.

Factorio
Shared: Automation · Base Building · Resource Management

Satisfactory
Shared: Automation · Base Building · Crafting

Oxygen Not Included
Shared: Colony Sim · Base Building · Resource Management

RimWorld
Shared: Colony Sim · Base Building · Sandbox

Prison Architect
Shared: Base Building · Colony Sim · Sandbox

Dyson Sphere Program
Shared: Automation · Base Building · Resource Management

shapez
Shared: Automation · Base Building · Resource Management

Factory Town
Shared: Automation · Base Building · Resource Management

Kingdoms and Castles
Shared: Colony Sim · Resource Management · Sandbox

Dwarf Fortress
Shared: Colony Sim · Base Building · Simulation

Manor Lords
Shared: Base Building · Simulation · Sandbox

Timberborn
Shared: Colony Sim · Automation · Sandbox

Stationeers
Shared: Automation · Base Building · Colony Sim

Captain of Industry
Shared: Automation · Base Building · Resource Management

Against the Storm
Shared: Base Building · Simulation · Colony Sim

The Last Caretaker
Shared: Automation · Base Building · Crafting

Frostpunk
Shared: Resource Management · Colony Sim · Base Building

The Crust
Shared: Automation · Base Building · Colony Sim

Banished
Shared: Colony Sim · Simulation · Sandbox

Cities: Skylines
Shared: Simulation · Sandbox · Building

Flotsam
Shared: Colony Sim · Base Building · Automation

Empires of the Undergrowth
Shared: Base Building · Colony Sim · Simulation

Hydroneer
Shared: Automation · Base Building · Sandbox

Techtonica
Shared: Automation · Base Building · Simulation