Games like Microbes and Machines
Games like Microbes and Machines include Vampire Survivors, BALL x PIT, Skul: The Hero Slayer, The Binding of Isaac: Rebirth, and Dead Cells. We matched them by the tags players give Microbes and Machines on Steam (Action, Action Roguelike, 2D, Roguelite, and Roguelike): closest matches first, and among equally close ones the better-known games.

Vampire Survivors
Shared: Action Roguelike · Roguelite · 2D

BALL x PIT
Shared: Action · Roguelite · Action Roguelike

Skul: The Hero Slayer
Shared: Action · Action Roguelike · 2D

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Roguelike · Pixel Graphics

Dead Cells
Shared: Action Roguelike · Roguelike · 2D

Megabonk
Shared: Action Roguelike · Roguelite · Roguelike

Nuclear Throne
Shared: Action Roguelike · Roguelike · Action

Halls of Torment
Shared: Action Roguelike · Roguelite · Action

Dungreed
Shared: Action Roguelike · Action · Roguelite

Death Must Die
Shared: Action Roguelike · Roguelite · Action

Enter the Gungeon
Shared: Action Roguelike · Roguelike · Pixel Graphics

Hades
Shared: Action Roguelike · Roguelite · Action

Star of Providence
Shared: Action Roguelike · Roguelite · Action

Rogue Legacy
Shared: Action Roguelike · Action · Roguelike

Nova Drift
Shared: Roguelite · Action Roguelike · Shoot 'Em Up

The Binding of Isaac
Shared: Action Roguelike · Roguelike · Action

Risk of Rain (2013)
Shared: Action Roguelike · Action · Roguelike

Risk of Rain 2
Shared: Action Roguelike · Action · Roguelike

Streets of Rogue
Shared: Action Roguelike · Roguelite · Action

UnderMine
Shared: Action Roguelike · Roguelite · Action

Sephiria
Shared: Action Roguelike · Roguelite · Roguelike

Hades II
Shared: Action · Roguelite · Roguelike

Boneraiser Minions
Shared: Action Roguelike · Roguelite · 2D

ScourgeBringer
Shared: Action · Roguelite · Action Roguelike