Games like MegaFactory Tycoon
Games like MegaFactory Tycoon include Prison Architect, Cities: Skylines, Dyson Sphere Program, Captain of Industry, and Oxygen Not Included. We matched them by the tags players give MegaFactory Tycoon on Steam (Simulation, Automation, Building, 2D, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Prison Architect
Shared: Simulation · Building · 2D

Cities: Skylines
Shared: Simulation · Building · Management

Dyson Sphere Program
Shared: Automation · Building · Simulation

Captain of Industry
Shared: Automation · Simulation · Resource Management

Oxygen Not Included
Shared: Building · Singleplayer · 2D

Factorio
Shared: Automation · Resource Management · Building

Cities: Skylines II
Shared: Simulation · Building · Singleplayer

Jurassic World Evolution
Shared: Simulation · Building · Management

Jurassic World Evolution 2
Shared: Building · Simulation · Management

Airport CEO
Shared: Simulation · Resource Management · Singleplayer

Production Line : Car factory simulation
Shared: Simulation · Automation · Management

Manor Lords
Shared: Simulation · Building · Strategy

Supermarket Simulator
Shared: Simulation · Management · Singleplayer

Planet Zoo
Shared: Simulation · Building · Management

shapez
Shared: Automation · Resource Management · Singleplayer

Project Highrise
Shared: Simulation · Building · Management

Planet Coaster
Shared: Simulation · Building · Management

Against the Storm
Shared: Simulation · Building · Strategy

Transport Fever 2
Shared: Simulation · Management · Building

shapez 2 - Factory
Shared: Automation · Building · Simulation

Another Brick in The Mall
Shared: Automation · Simulation · Building

Automation Empire
Shared: Simulation · Automation · Building

Little Big Workshop
Shared: Simulation · Building · Automation

Frostpunk
Shared: Building · Resource Management · Simulation