Games like MegaFactory Titan
Games like MegaFactory Titan include Dyson Sphere Program, Captain of Industry, Cities: Skylines, Factorio, and Manor Lords. We matched them by the tags players give MegaFactory Titan on Steam (Building, Automation, Resource Management, Base Building, and Procedural Generation): closest matches first, and among equally close ones the better-known games.

Dyson Sphere Program
Shared: Automation · Building · Base Building

Captain of Industry
Shared: Automation · Resource Management · Base Building

Cities: Skylines
Shared: Building · City Builder · Management

Factorio
Shared: Automation · Resource Management · Base Building

Manor Lords
Shared: Base Building · City Builder · Building

Prison Architect
Shared: Building · Base Building · City Builder

Against the Storm
Shared: Building · Base Building · City Builder

Kingdoms and Castles
Shared: Resource Management · City Builder · Building

Frostpunk
Shared: Resource Management · City Builder · Building

Oxygen Not Included
Shared: Base Building · Building · Resource Management

Cities: Skylines II
Shared: Building · City Builder · Management

The Crust
Shared: Automation · Base Building · Resource Management

Satisfactory
Shared: Automation · Base Building · Building

Workers & Resources: Soviet Republic
Shared: Base Building · Building · City Builder

Factory Town
Shared: Automation · Resource Management · Base Building

Automation Empire
Shared: Automation · Building · Base Building

Farthest Frontier
Shared: Building · Resource Management · City Builder

Jurassic World Evolution
Shared: Building · Management · City Builder

IXION
Shared: Resource Management · City Builder · Building

shapez 2 - Factory
Shared: Automation · Building · Management

shapez
Shared: Automation · Resource Management · Base Building

Timberborn
Shared: Automation · Building · City Builder

Jurassic World Evolution 2
Shared: Building · Management · Resource Management

InfraSpace
Shared: Automation · Resource Management · Building