Games like Mechanical Defense Line
Games like Mechanical Defense Line include Slay the Spire, Balatro, Inscryption, Monster Train, and Slay the Spire 2. We matched them by the tags players give Mechanical Defense Line on Steam (Card Battler, Turn-Based Tactics, Bullet Hell, Strategy, and Roguelite): closest matches first, and among equally close ones the better-known games.

Slay the Spire
Shared: Card Battler · Card Game · Strategy

Balatro
Shared: Card Game · Strategy · Roguelite

Inscryption
Shared: Card Battler · Card Game · Roguelite

Monster Train
Shared: Card Battler · Turn-Based Tactics · Roguelite

Slay the Spire 2
Shared: Card Game · Strategy · Card Battler

Vampire Survivors
Shared: Bullet Hell · Roguelite · Casual

Stacklands
Shared: Card Battler · Card Game · Roguelite

Wildfrost
Shared: Card Battler · Turn-Based Tactics · Card Game

Griftlands
Shared: Card Battler · Roguelite · Card Game

Dream of Corpse Lady
Shared: Card Battler · Strategy · Turn-Based Tactics

Trials of Fire
Shared: Card Battler · Turn-Based Tactics · Roguelite

Dicey Dungeons
Shared: Card Battler · Roguelite · Strategy

Black Book
Shared: Card Battler · Turn-Based Tactics · Card Game

Ratropolis
Shared: Card Battler · Strategy · Roguelite

9 Kings
Shared: Strategy · Card Game · Card Battler

StarVaders
Shared: Turn-Based Tactics · Roguelite · Card Game

Dungeons & Degenerate Gamblers
Shared: Strategy · Card Battler · Card Game

DICEOMANCER
Shared: Card Battler · Strategy · Card Game

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Card Battler · Strategy · Card Game

Roguebook
Shared: Card Game · Strategy · Roguelite

Big Bia
Shared: Strategy · Roguelite · Card Battler

LONESTAR
Shared: Turn-Based Tactics · Card Battler · Strategy

Ballionaire
Shared: Strategy · Casual · Roguelite

Super Fantasy Kingdom
Shared: Strategy · Roguelite · Card Game