Games like Mayhem Maidens
Games like Mayhem Maidens include Balatro, Slay the Spire, Luck be a Landlord, Vampire Survivors, and Muse Dash. We matched them by the tags players give Mayhem Maidens on Steam (Tower Defense, Singleplayer, Anime, Roguelike Deckbuilder, and Female Protagonist): closest matches first, and among equally close ones the better-known games.

Balatro
Shared: Roguelike Deckbuilder · Singleplayer · Pixel Graphics

Slay the Spire
Shared: Roguelike Deckbuilder · Singleplayer · Deckbuilding

Luck be a Landlord
Shared: Roguelike Deckbuilder · Roguelite · Pixel Graphics

Vampire Survivors
Shared: Pixel Graphics · Singleplayer · Roguelite

Muse Dash
Shared: Anime · Female Protagonist · Singleplayer

Chrono Ark
Shared: Anime · Roguelike Deckbuilder · Female Protagonist

Heretic's Fork
Shared: Tower Defense · Roguelike Deckbuilder · Deckbuilding

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Singleplayer · 2D

RACCOIN: Coin Pusher Roguelike
Shared: Singleplayer · Roguelike Deckbuilder · Deckbuilding

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Singleplayer · 2D

Rabi-Ribi
Shared: Anime · Female Protagonist · Pixel Graphics

Marfusha:Sentinel Girls
Shared: Anime · Female Protagonist · Pixel Graphics

Ratropolis
Shared: Singleplayer · 2D · Roguelite

Slay the Spire 2
Shared: Roguelike Deckbuilder · Deckbuilding · Strategy

Emberward
Shared: Tower Defense · Singleplayer · Roguelite

Bloons TD 6
Shared: Tower Defense · Singleplayer · Strategy

Phantom Rose
Shared: Roguelike Deckbuilder · Anime · Female Protagonist

Tower Tactics: Liberation
Shared: Tower Defense · Roguelike Deckbuilder · Singleplayer

Kingdom Rush - Tower Defense
Shared: Tower Defense · Singleplayer · 2D

Kingdom Rush 5: Alliance TD
Shared: Tower Defense · Singleplayer · 2D

Peglin
Shared: Roguelite · Deckbuilding · Pixel Graphics

Skul: The Hero Slayer
Shared: Pixel Graphics · Singleplayer · 2D

Celeste
Shared: Pixel Graphics · Singleplayer · Female Protagonist

Witchs Apocalyptic Journey
Shared: Roguelike Deckbuilder · Anime · Pixel Graphics