Games like Mars or Die!
Games like Mars or Die! include Oxygen Not Included, RimWorld, Dyson Sphere Program, FTL: Faster Than Light, and Space Engineers. We matched them by the tags players give Mars or Die! on Steam (Strategy, Action, Indie, Tower Defense, and Space): closest matches first, and among equally close ones the better-known games.

Oxygen Not Included
Shared: Base Building · Singleplayer · Strategy

RimWorld
Shared: Strategy · Base Building · Survival

Dyson Sphere Program
Shared: Space · Base Building · Strategy

FTL: Faster Than Light
Shared: Strategy · Space · Indie

Space Engineers
Shared: Space · Survival · Base Building

Taur
Shared: Strategy · Action · Tower Defense

The Alters
Shared: Strategy · Base Building · Survival

Spacebase DF-9
Shared: Strategy · Space · Indie

Plants vs. Zombies GOTY Edition
Shared: Strategy · Tower Defense · Singleplayer

Orcs Must Die!
Shared: Action · Strategy · Tower Defense

Sanctum 2
Shared: Strategy · Tower Defense · Action

They Are Billions
Shared: Strategy · Base Building · Tower Defense

Cosmoteer: Starship Architect & Commander
Shared: Strategy · Space · Indie

Space Haven
Shared: Strategy · Space · Base Building

Planetbase
Shared: Strategy · Space · Base Building

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Indie

Breathedge
Shared: Space · Indie · Singleplayer

Kingdom Two Crowns
Shared: Tower Defense · Strategy · Singleplayer

Bloons TD 6
Shared: Strategy · Tower Defense · Singleplayer

Creeper World 3: Arc Eternal
Shared: Strategy · Tower Defense · Indie

Space Run
Shared: Strategy · Tower Defense · Indie

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · Singleplayer

The Riftbreaker
Shared: Tower Defense · Base Building · Survival

Reassembly
Shared: Strategy · Space · Action