Games like Manifest Destiny
Games like Manifest Destiny include Portal 2, SANABI, Trine 2: Complete Story, LIMBO, and Pipistrello and the Cursed Yoyo. We matched them by the tags players give Manifest Destiny on Steam (Puzzle Platformer, 2D, Retro, Action-Adventure, and Top-Down): closest matches first, and among equally close ones the better-known games.

Portal 2
Shared: Puzzle Platformer · Puzzle · Platformer

SANABI
Shared: 2D · 2D Platformer · Story Rich

Trine 2: Complete Story
Shared: Puzzle Platformer · Action-Adventure · Platformer

LIMBO
Shared: Puzzle Platformer · 2D · Puzzle

Pipistrello and the Cursed Yoyo
Shared: Action-Adventure · Top-Down · Retro

Braid
Shared: Puzzle Platformer · 2D · Puzzle

Defy Gravity Extended
Shared: Puzzle Platformer · 2D · Platformer

Out There Somewhere
Shared: 2D · Platformer · Puzzle

Sanfu
Shared: 2D · Puzzle · Puzzle Platformer

FEZ
Shared: Puzzle · Platformer · Puzzle Platformer

Celeste
Shared: 2D · Platformer · 2D Platformer

Webbed
Shared: Puzzle Platformer · 2D · 2D Platformer

ANIMAL WELL
Shared: Puzzle Platformer · Puzzle · 2D

The Messenger
Shared: Retro · 2D · Platformer

UFO 50
Shared: Retro · 2D · Indie

Trine 5: A Clockwork Conspiracy
Shared: Puzzle Platformer · Action-Adventure · 2D

Mina the Hollower
Shared: Action-Adventure · Top-Down · 2D

ANTONBLAST
Shared: 2D · 2D Platformer · Puzzle Platformer

ElecHead
Shared: Puzzle Platformer · Puzzle · Retro

Planet of Lana
Shared: Puzzle Platformer · Puzzle · 2D Platformer

INSIDE
Shared: Puzzle Platformer · Story Rich · Puzzle

Öoo
Shared: Puzzle Platformer · 2D · Puzzle

Nihilumbra
Shared: Puzzle Platformer · 2D · Casual

BlazBlue Entropy Effect
Shared: 2D · Action-Adventure · Platformer