Games like Mainframe Defenders
Games like Mainframe Defenders include Elin, Stoneshard, Wall World, Legend Creatures(传奇生物), and Terraria. We matched them by the tags players give Mainframe Defenders on Steam (Exploration, Tactical RPG, Traditional Roguelike, Roguelite, and Sandbox): closest matches first, and among equally close ones the better-known games.

Elin
Shared: Roguelike · Traditional Roguelike · RPG

Stoneshard
Shared: Roguelike · RPG · Strategy

Wall World
Shared: Roguelite · Exploration · Roguelike

Legend Creatures(传奇生物)
Shared: Exploration · Roguelite · Roguelike

Terraria
Shared: Sandbox · Exploration · 2D

鬼谷八荒 Tale of Immortal
Shared: Tactical RPG · Sandbox · RPG

Into the Breach
Shared: Strategy · Roguelike · Roguelite

Nordic Ashes: Survivors of Ragnarok
Shared: Exploration · Roguelite · Roguelike

Home Behind 2
Shared: Strategy · Roguelike · RPG

9 Kings
Shared: Strategy · Roguelike · RPG

Pathway
Shared: Exploration · Tactical RPG · Roguelite

Noita
Shared: Roguelike · Sandbox · 2D

Soulash 2
Shared: Exploration · Sandbox · Traditional Roguelike

Vampire Survivors
Shared: Roguelite · Roguelike · 2D

Darkest Dungeon®
Shared: Roguelike · RPG · Turn-Based Combat

Star Renegades
Shared: Roguelike · Roguelite · Tactical RPG

Peglin
Shared: Roguelite · Roguelike · Strategy

Slay the Spire 2
Shared: Roguelike · Strategy · Roguelite

Renowned Explorers: International Society
Shared: Strategy · Exploration · RPG

The Scroll of Taiwu : Beyond The Dome
Shared: Sandbox · RPG · Strategy

Super Fantasy Kingdom
Shared: Strategy · Roguelite · Roguelike

The Last Spell
Shared: Strategy · RPG · Tactical RPG

Balatro
Shared: Roguelike · Strategy · Roguelite

Loop Hero
Shared: Roguelike · Roguelite · Pixel Graphics