Games like Little Buddy
Games like Little Buddy include Potion Craft: Alchemist Simulator, Digseum, Unpacking, Stardew Valley, and Shelldiver. We matched them by the tags players give Little Buddy on Steam (Time Management, Idler, Crafting, Point & Click, and 2D): closest matches first, and among equally close ones the better-known games.

Potion Craft: Alchemist Simulator
Shared: Crafting · Simulation · Relaxing

Digseum
Shared: Idler · Casual · Simulation

Unpacking
Shared: Casual · Cute · Relaxing

Stardew Valley
Shared: Crafting · Simulation · Relaxing

Shelldiver
Shared: Idler · Casual · 2D

Click the Button
Shared: Idler · Casual · Point & Click

Melvor Idle
Shared: Idler · Casual · 2D

Cookie Clicker
Shared: Idler · Casual · 2D

Fantasy Aquarium
Shared: Idler · Casual · Cute

Papers, Please
Shared: Point & Click · Simulation · Indie

Tiny Pasture
Shared: Idler · Cute · Casual

Maltese's Fluffy Onsen
Shared: Idler · Simulation · Casual

Nodebuster
Shared: Idler · Casual · 2D

Touhou Mystia's Izakaya
Shared: Time Management · Casual · Simulation

Chill Pulse
Shared: Idler · Casual · Point & Click

Sticky Business
Shared: Casual · Cute · Simulation

Cast n Chill
Shared: Idler · Relaxing · Casual

A Little to the Left
Shared: Point & Click · Relaxing · Casual

Papa's Freezeria Deluxe
Shared: Time Management · Casual · Simulation

A Game About Feeding A Black Hole
Shared: Idler · Casual · 2D

Click and Conquer
Shared: Idler · Casual · Simulation

PomoFarm
Shared: Time Management · Idler · Casual

Hidden Folks
Shared: Casual · Point & Click · 2D

MyVoiceZoo
Shared: Casual · Idler · Simulation