Games like Lifeforms: Binary Fission
Games like Lifeforms: Binary Fission include Hades, Megabonk, Totally Accurate Battle Simulator, We Who Are About To Die, and Vampire Survivors. We matched them by the tags players give Lifeforms: Binary Fission on Steam (Action Roguelike, Action, Simulation, Roguelite, and Strategy): closest matches first, and among equally close ones the better-known games.

Hades
Shared: Action Roguelike · Roguelite · Action

Megabonk
Shared: Action Roguelike · Roguelite · Action

Totally Accurate Battle Simulator
Shared: Simulation · Sandbox · Strategy

We Who Are About To Die
Shared: Action · Roguelite · Simulation

Vampire Survivors
Shared: Action Roguelike · Roguelite · Indie

Everything is Crab: The Animal Evolution Roguelite
Shared: Action Roguelike · Roguelite · Strategy

BALL x PIT
Shared: Action · Roguelite · Action Roguelike

Ultimate Epic Battle Simulator 2
Shared: Simulation · Action · Strategy

Hades II
Shared: Action · Roguelite · Action Roguelike

Halls of Torment
Shared: Action Roguelike · Roguelite · Action

Skul: The Hero Slayer
Shared: Action · Action Roguelike · Indie

Total Tank Simulator
Shared: Action · Simulation · Strategy

The Binding of Isaac
Shared: Action Roguelike · Indie · Action

SPORE™
Shared: Simulation · Sandbox · God Game

Shape of Dreams
Shared: Action Roguelike · Roguelite · Action

Risk of Rain 2
Shared: Action Roguelike · Action · Roguelite

Mount & Blade II: Bannerlord
Shared: Strategy · Action · Sandbox

Monsters are Coming!
Shared: Action · Roguelite · Action Roguelike

20 Minutes Till Dawn
Shared: Action Roguelike · Roguelite · Survival

Ultimate Epic Battle Simulator
Shared: Simulation · Action · Sandbox

Sipho
Shared: Action Roguelike · Action · Simulation

Noita
Shared: Sandbox · Action Roguelike · Indie

SYNTHETIK: Legion Rising
Shared: Action · Roguelite · Action Roguelike

Feed and Grow: Fish
Shared: Simulation · Action · Indie