Games like Life is Paine
Games like Life is Paine include Return to Monkey Island, Deponia, There Is No Game: Wrong Dimension, Chants of Sennaar, and CHUCHEL. We matched them by the tags players give Life is Paine on Steam (Adventure, Point & Click, Comedy, 2D, and Cartoony): closest matches first, and among equally close ones the better-known games.

Return to Monkey Island
Shared: Adventure · Point & Click · Comedy

Deponia
Shared: Adventure · Point & Click · Comedy

There Is No Game: Wrong Dimension
Shared: Point & Click · Adventure · Comedy

Chants of Sennaar
Shared: Adventure · Point & Click · Singleplayer

CHUCHEL
Shared: Comedy · Point & Click · Cartoony

Lost in Play
Shared: Point & Click · 2D · Puzzle

Deponia: The Complete Journey
Shared: Adventure · Point & Click · Comedy

Chaos on Deponia
Shared: Adventure · Point & Click · Comedy

Deponia Doomsday
Shared: Adventure · Point & Click · Comedy

Gorogoa
Shared: Point & Click · Puzzle · Singleplayer

Goodbye Deponia
Shared: Adventure · Point & Click · Comedy

Broken Age
Shared: Adventure · Point & Click · Comedy

Storyteller
Shared: Point & Click · Adventure · 2D

Machinarium
Shared: Point & Click · 2D · Adventure

Randal's Monday
Shared: Adventure · Point & Click · Comedy

Thank Goodness You're Here!
Shared: Adventure · Comedy · 2D

Day of the Tentacle Remastered
Shared: Adventure · Point & Click · Comedy

Neighbours back From Hell
Shared: Point & Click · Comedy · Adventure

The Henry Stickmin Collection
Shared: Comedy · Point & Click · Singleplayer

The Secret of Monkey Island: Special Edition
Shared: Adventure · Point & Click · Comedy

McPixel
Shared: Point & Click · Comedy · Adventure

Edna & Harvey: The Breakout
Shared: Adventure · Point & Click · Comedy

Thimbleweed Park™
Shared: Adventure · Point & Click · Comedy

Rusty Lake Paradise
Shared: Point & Click · Adventure · Puzzle