Games like Laboratory X-29
Games like Laboratory X-29 include Voidigo, Dead Cells, The Binding of Isaac: Rebirth, Enter the Gungeon, and BALL x PIT. We matched them by the tags players give Laboratory X-29 on Steam (Shoot 'Em Up, Twin Stick Shooter, Action Roguelike, Top-Down Shooter, and Colorful): closest matches first, and among equally close ones the better-known games.

Voidigo
Shared: Twin Stick Shooter · Action Roguelike · Shoot 'Em Up

Dead Cells
Shared: Action Roguelike · Pixel Graphics · Roguelite

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Pixel Graphics · Difficult

Enter the Gungeon
Shared: Action Roguelike · Pixel Graphics · Twin Stick Shooter

BALL x PIT
Shared: Roguelite · Shoot 'Em Up · Action Roguelike

Nuclear Throne
Shared: Action Roguelike · Pixel Graphics · Difficult

Tiny Rogues
Shared: Action Roguelike · Top-Down Shooter · Roguelite

Star of Providence
Shared: Shoot 'Em Up · Action Roguelike · Roguelite

Skul: The Hero Slayer
Shared: Action Roguelike · Pixel Graphics · Roguelite

20 Minutes Till Dawn
Shared: Action Roguelike · Shoot 'Em Up · Top-Down Shooter

SYNTHETIK: Legion Rising
Shared: Top-Down Shooter · Action Roguelike · Roguelite

Dead Estate
Shared: Action Roguelike · Twin Stick Shooter · Shoot 'Em Up

Vampire Survivors
Shared: Action Roguelike · Roguelite · Pixel Graphics

The Binding of Isaac
Shared: Action Roguelike · Difficult · Replay Value

Turnip Boy Robs a Bank
Shared: Shoot 'Em Up · Top-Down Shooter · Roguelite

Super Amazing Wagon Adventure
Shared: Shoot 'Em Up · Action Roguelike · Twin Stick Shooter

SNKRX
Shared: Action Roguelike · Shoot 'Em Up · Top-Down Shooter

Nova Drift
Shared: Shoot 'Em Up · Action Roguelike · Roguelite

Blazing Beaks
Shared: Action Roguelike · Top-Down Shooter · Roguelite

Relic Hunters Zero: Remix
Shared: Twin Stick Shooter · Top-Down Shooter · Action Roguelike

The Crackpet Show
Shared: Twin Stick Shooter · Action Roguelike · Shoot 'Em Up

Streets of Rogue
Shared: Action Roguelike · Roguelite · Pixel Graphics

SYNTHETIK 2
Shared: Action Roguelike · Twin Stick Shooter · Top-Down Shooter

Noita
Shared: Pixel Graphics · Difficult · Action Roguelike