Games like Isolation Story
Games like Isolation Story include My Time at Portia, Palworld, Volcano Princess, Stardew Valley, and WolfQuest: Anniversary Edition. We matched them by the tags players give Isolation Story on Steam (Survival, Outbreak Sim, Life Sim, Open World, and RPG): closest matches first, and among equally close ones the better-known games.

My Time at Portia
Shared: Life Sim · Open World · RPG

Palworld
Shared: Survival · Open World · Creature Collector

Volcano Princess
Shared: Life Sim · RPG · Visual Novel

Stardew Valley
Shared: Life Sim · RPG · Open World

WolfQuest: Anniversary Edition
Shared: Survival · Life Sim · Open World

Kenshi
Shared: Survival · Open World · RPG

7 Days to Die
Shared: Survival · Open World · RPG

Project Zomboid
Shared: Survival · Open World · RPG

Enshrouded
Shared: Survival · Open World · RPG

S.T.A.L.K.E.R. 2: Heart of Chornobyl - Standard Edition
Shared: Survival · Open World · RPG

Once Human
Shared: Survival · Open World · RPG

Valheim
Shared: Survival · Open World · RPG

Don't Starve Together
Shared: Survival · Open World · RPG

The Long Dark
Shared: Survival · Open World · Exploration

TOGETHER BnB
Shared: Open World · Life Sim · RPG

Fallout 76
Shared: Open World · Survival · RPG

Core Keeper
Shared: Survival · Open World · Exploration

Bellwright
Shared: Survival · Open World · RPG

Conan Exiles Enhanced
Shared: Survival · Open World · RPG

Rust
Shared: Survival · Open World · RPG

Sons Of The Forest
Shared: Survival · Open World · Exploration

DYSMANTLE
Shared: Survival · Open World · RPG

School Days
Shared: Life Sim · Time Management · Exploration

Hello Kitty Island Adventure
Shared: Open World · Life Sim · Casual