Games like Isolate ME!
Games like Isolate ME! include Vampire Survivors, Plague Inc: Evolved, Stardew Valley, Shower With Your Dad Simulator 2015: Do You Still Shower With Your Dad, and The Coin Game. We matched them by the tags players give Isolate ME! on Steam (Casual, Simulation, Procedural Generation, Outbreak Sim, and Arcade): closest matches first, and among equally close ones the better-known games.
Vampire Survivors
Shared: Roguelite · Casual · 2D
Plague Inc: Evolved
Shared: Simulation · Outbreak Sim · Casual
Stardew Valley
Shared: Simulation · Life Sim · Pixel Graphics
Shower With Your Dad Simulator 2015: Do You Still Shower With Your Dad
Shared: Casual · Arcade · 2D
The Coin Game
Shared: Casual · Arcade · Simulation
Timberman
Shared: Casual · Pixel Graphics · Arcade
Luck be a Landlord
Shared: Procedural Generation · Simulation · Roguelite
DAVE THE DIVER
Shared: Casual · Pixel Graphics · Simulation
Megabonk
Shared: Roguelite · Arcade · Casual
BALL x PIT
Shared: Arcade · Roguelite · Action
To The Core
Shared: Casual · Procedural Generation · Arcade
Touhou Mystia's Izakaya
Shared: Casual · Simulation · Pixel Graphics
Shelldiver
Shared: Casual · Arcade · Simulation
BidKing
Shared: Casual · Simulation · Life Sim
Nodebuster
Shared: Casual · Simulation · Arcade
The Escapists
Shared: Simulation · Pixel Graphics · 2D
Chinese Parents
Shared: Simulation · Casual · Life Sim
Unpacking
Shared: Casual · Simulation · Pixel Graphics
Game Dev Tycoon
Shared: Simulation · Casual · 2D
Streamer Life Simulator
Shared: Simulation · Casual · Life Sim
Space Warlord Organ Trading Simulator
Shared: Arcade · Casual · Roguelite
Russian Life Simulator
Shared: Simulation · Casual · 2D
UnderMine
Shared: Roguelite · Pixel Graphics · Procedural Generation
Astro Prospector
Shared: Casual · Roguelite · Simulation