Games like Islets Defense
Games like Islets Defense include Kingdom Two Crowns, Thronefall, Frostpunk, They Are Billions, and Age of Empires II (Retired). We matched them by the tags players give Islets Defense on Steam (Strategy, Tower Defense, City Builder, Resource Management, and Base Building): closest matches first, and among equally close ones the better-known games.

Kingdom Two Crowns
Shared: Tower Defense · City Builder · Strategy

Thronefall
Shared: Strategy · Tower Defense · City Builder

Frostpunk
Shared: City Builder · Strategy · Resource Management

They Are Billions
Shared: Strategy · Base Building · Tower Defense

Age of Empires II (Retired)
Shared: Strategy · City Builder · Base Building

Mindustry
Shared: Tower Defense · Base Building · Strategy

Farthest Frontier
Shared: Strategy · City Builder · Resource Management

Manor Lords
Shared: Strategy · City Builder · Base Building

Cities: Skylines
Shared: City Builder · Strategy · Building

Stronghold: Definitive Edition
Shared: Strategy · City Builder · Building

Prison Architect
Shared: Strategy · Base Building · Building

Against the Storm
Shared: Strategy · City Builder · Base Building

Oxygen Not Included
Shared: Base Building · Resource Management · Building

Stronghold Crusader: Definitive Edition
Shared: Strategy · City Builder · Tower Defense

Kingdom Rush 5: Alliance TD
Shared: Strategy · Tower Defense · 2D

Foundation
Shared: City Builder · Strategy · Resource Management

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · 2D

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

Factorio
Shared: Resource Management · Base Building · Strategy

The King is Watching
Shared: Tower Defense · Base Building · Strategy

Kingdom Rush Vengeance - Tower Defense
Shared: Strategy · Tower Defense · 2D

Bee Island
Shared: Strategy · Tower Defense · City Builder

Sid Meier’s Civilization® VI
Shared: Strategy · Turn-Based Strategy · City Builder

Bloons TD 6
Shared: Strategy · Tower Defense · Singleplayer