Games like Isekai Guild Simulation
Games like Isekai Guild Simulation include Dealer's Life 2, TCG Card Shop Simulator, ReStory: Chill Electronics Repairs, Probably Stolen - Cyberpunk Shopkeeper Sim, and Dressmaker. We matched them by the tags players give Isekai Guild Simulation on Steam (Shop Keeper, Job Simulator, Simulation, 2D, and Economy): closest matches first, and among equally close ones the better-known games.

Dealer's Life 2
Shared: Job Simulator · Shop Keeper · Economy

TCG Card Shop Simulator
Shared: Simulation · Economy · Shop Keeper

ReStory: Chill Electronics Repairs
Shared: Job Simulator · Economy · Shop Keeper

Probably Stolen - Cyberpunk Shopkeeper Sim
Shared: Shop Keeper · Simulation · Job Simulator

Dressmaker
Shared: Job Simulator · Simulation · Singleplayer

Shop Titans
Shared: Shop Keeper · Economy · Simulation

Retro Rewind - Video Store Simulator
Shared: Shop Keeper · Simulation · Singleplayer

Game Dev Tycoon
Shared: Simulation · Economy · 2D

Potion Craft: Alchemist Simulator
Shared: Simulation · Singleplayer · 2D

Supermarket Simulator
Shared: Simulation · Economy · Singleplayer

Dealer's Life
Shared: Job Simulator · Shop Keeper · Economy

Kingdom Rush Frontiers - Tower Defense
Shared: 2D · Singleplayer · Fantasy

Papa's Freezeria Deluxe
Shared: Simulation · Job Simulator · Casual

Tavern Manager Simulator 🍻
Shared: Simulation · Economy · Singleplayer

Shawarma Legend
Shared: Simulation · 2D · Singleplayer

BidKing
Shared: Simulation · Shop Keeper · Casual

Gas Station Simulator
Shared: Simulation · Economy · Singleplayer

Fell & Sell
Shared: Shop Keeper · Simulation · Economy

Storage Hunter Simulator
Shared: Shop Keeper · Job Simulator · Economy

Melvor Idle
Shared: 2D · Singleplayer · Casual

Kingdom Rush - Tower Defense
Shared: 2D · Singleplayer · Fantasy

Bear and Breakfast
Shared: Economy · Simulation · Singleplayer

Teddy's Haven
Shared: Shop Keeper · Simulation · Fantasy

Megastore Simulator
Shared: Simulation · Economy · Singleplayer