Games like Irradiate 235
Games like Irradiate 235 include People Playground, Totally Accurate Battle Simulator, Prison Architect, Oxygen Not Included, and Kerbal Space Program. We matched them by the tags players give Irradiate 235 on Steam (Simulation, Sandbox, 2D, Colorful, and Stylized): closest matches first, and among equally close ones the better-known games.

People Playground
Shared: Sandbox · 2D · Simulation

Totally Accurate Battle Simulator
Shared: Simulation · Sandbox · Colorful

Prison Architect
Shared: Simulation · Sandbox · Building

Oxygen Not Included
Shared: 2D · Sandbox · Simulation

Kerbal Space Program
Shared: Simulation · Sandbox · Building

鬼谷八荒 Tale of Immortal
Shared: Simulation · Sandbox · Singleplayer

Space Engineers
Shared: Sandbox · Simulation · Building

Garry's Mod
Shared: Sandbox · Simulation · Building

Townscaper
Shared: Sandbox · Simulation · Building

Planet Coaster
Shared: Simulation · Sandbox · Building

Terraria
Shared: Sandbox · 2D · Building

Poly Bridge
Shared: Simulation · Sandbox · Building

Spaceflight Simulator
Shared: Sandbox · Simulation · 2D

Graveyard Keeper
Shared: Simulation · Sandbox · Indie

Game Dev Tycoon
Shared: Simulation · Indie · 2D

Dyson Sphere Program
Shared: Simulation · Automation · Sandbox

Cities: Skylines
Shared: Simulation · Sandbox · Building

Automation - The Car Company Tycoon Game
Shared: Simulation · Sandbox · Building

House Flipper
Shared: Simulation · Sandbox · Singleplayer

Cities: Skylines II
Shared: Simulation · Sandbox · Building

Potion Craft: Alchemist Simulator
Shared: Simulation · 2D · Sandbox

Stardew Valley
Shared: Simulation · Sandbox · Indie

Paralives
Shared: Simulation · Sandbox · Indie

Factorio
Shared: Sandbox · Automation · 2D