Games like Irezumi Defenders
Games like Irezumi Defenders include Stacklands, Slay the Spire, Slay the Spire 2, Balatro, and RimWorld. We matched them by the tags players give Irezumi Defenders on Steam (Strategy, Card Game, Tower Defense, Management, and Survival): closest matches first, and among equally close ones the better-known games.

Stacklands
Shared: Card Game · Management · Survival

Slay the Spire
Shared: Card Game · Strategy · Card Battler

Slay the Spire 2
Shared: Card Game · Strategy · Deckbuilding

Balatro
Shared: Card Game · Strategy · Deckbuilding

RimWorld
Shared: Strategy · Survival · Management

Cities: Skylines
Shared: Strategy · Management · City Builder

Banished
Shared: Strategy · City Builder · Survival

Ratropolis
Shared: Strategy · Card Battler · Card Game

Frostpunk
Shared: Strategy · Survival · City Builder

Esports Godfather
Shared: Strategy · Management · Card Battler

Inscryption
Shared: Card Game · Card Battler · Deckbuilding

Manor Lords
Shared: Strategy · City Builder · Management

Frostpunk 2
Shared: Strategy · Survival · City Builder

WitchHand
Shared: Strategy · Card Game · Management

Rise to Ruins
Shared: Tower Defense · Strategy · Survival

Oxygen Not Included
Shared: Survival · Management · Strategy

Against the Storm
Shared: Strategy · Management · City Builder

Endzone - A World Apart
Shared: Strategy · Survival · City Builder

Game Dev Tycoon
Shared: Strategy · Management · Simulation

Plants vs. Zombies GOTY Edition
Shared: Strategy · Tower Defense · Singleplayer

Library Of Ruina
Shared: Card Game · Strategy · Deckbuilding

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Strategy · Card Battler · Card Game

This War of Mine
Shared: Strategy · Survival · Simulation

They Are Billions
Shared: Strategy · Survival · Tower Defense