Games like Infectra
Games like Infectra include They Are Billions, Stronghold Crusader: Definitive Edition, Thronefall, Stronghold: Definitive Edition, and Creeper World 4. We matched them by the tags players give Infectra on Steam (Strategy, Puzzle, RTS, Tower Defense, and Colony Sim): closest matches first, and among equally close ones the better-known games.

They Are Billions
Shared: Strategy · Colony Sim · RTS

Stronghold Crusader: Definitive Edition
Shared: Strategy · Real Time Tactics · Colony Sim

Thronefall
Shared: Strategy · Tower Defense · Minimalist

Stronghold: Definitive Edition
Shared: Strategy · RTS · Real Time Tactics

Creeper World 4
Shared: Tower Defense · RTS · Real Time Tactics

Age of Darkness: Final Stand
Shared: Strategy · Tower Defense · RTS

Artisan TD
Shared: Strategy · Tower Defense · Puzzle

Kingdom Two Crowns
Shared: Tower Defense · Strategy · Minimalist

DG2: Defense Grid 2
Shared: Strategy · Tower Defense · RTS

Stronghold HD (2012)
Shared: Real Time Tactics · Colony Sim · Tower Defense

Planetary Annihilation: TITANS
Shared: Strategy · RTS · Real Time Tactics

Aliens: Dark Descent
Shared: Strategy · RTS · Real Time Tactics

Age of Mythology: Retold
Shared: Strategy · RTS · 3D

Bloons TD 6
Shared: Strategy · Tower Defense · 3D

ISLANDERS
Shared: Strategy · Puzzle · Colony Sim

Kingdom Heroes 8
Shared: RTS · Strategy · Real Time Tactics

Mindustry
Shared: Tower Defense · Strategy · RTS

Bad North: Jotunn Edition
Shared: Tower Defense · Real Time Tactics · RTS

RimWorld
Shared: Strategy · Colony Sim · Base Building

Minimalist Tower Defense
Shared: Strategy · Tower Defense · Real Time Tactics

Bee Island
Shared: Strategy · Tower Defense · Minimalist

Tower Dominion
Shared: Strategy · Tower Defense · RTS

Mini Motorways
Shared: Strategy · Puzzle · Minimalist

Lessaria: Fantasy Kingdom Sim
Shared: Strategy · RTS · Colony Sim