Games like Infect and Destroy
Games like Infect and Destroy include Plague Inc: Evolved, Infection Free Zone, Dead Age, Feed and Grow: Fish, and Game Dev Tycoon. We matched them by the tags players give Infect and Destroy on Steam (Outbreak Sim, Action, Indie, Casual, and Simulation): closest matches first, and among equally close ones the better-known games.

Plague Inc: Evolved
Shared: Outbreak Sim · Indie · Simulation

Infection Free Zone
Shared: Strategy · Zombies · Simulation

Dead Age
Shared: Strategy · Zombies · Casual

Feed and Grow: Fish
Shared: Simulation · Action · Indie

Game Dev Tycoon
Shared: Indie · Simulation · Casual

EmergeNYC
Shared: Action · Simulation · Early Access

Infectonator 3: Apocalypse
Shared: Outbreak Sim · Indie · Simulation

No More Room in Hell 2
Shared: Action · Zombies · Indie

Ultimate Epic Battle Simulator
Shared: Simulation · Action · Strategy

Achievement Clicker
Shared: Casual · Indie · Action

Mini Motorways
Shared: Casual · Simulation · Strategy

Total Tank Simulator
Shared: Action · Simulation · Strategy

Bomber Crew
Shared: Simulation · Strategy · Indie

Plebby Quest: The Crusades
Shared: Indie · Casual · Strategy

Project Zomboid
Shared: Zombies · Survival · Indie

Witch It
Shared: Indie · Casual · Action

ShellShock Live
Shared: Action · Strategy · Casual

Who's Your Daddy?!
Shared: Simulation · Strategy · Casual

Plants vs. Zombies GOTY Edition
Shared: Casual · Strategy · Zombies

Deadly Days
Shared: Action · Indie · Casual

Space Pirates And Zombies 2
Shared: Action · Indie · Strategy

Barotrauma
Shared: Survival · Simulation · Survival Horror

Resident Evil 4
Shared: Action · Survival Horror · Zombies

The Escapists
Shared: Strategy · Indie · Action