Games like HyphoSphere
Games like HyphoSphere include Cookie Clicker, Digseum, Shelldiver, Keep on Mining!, and Nodebuster. We matched them by the tags players give HyphoSphere on Steam (Casual, Point & Click, Colony Sim, Idler, and Incremental): closest matches first, and among equally close ones the better-known games.

Cookie Clicker
Shared: Casual · Idler · Incremental

Digseum
Shared: Casual · Incremental · Idler

Shelldiver
Shared: Casual · Incremental · Idler

Keep on Mining!
Shared: Casual · Idler · Incremental

Nodebuster
Shared: Casual · Incremental · Idler

Click the Button
Shared: Casual · Idler · Incremental

All Hail the Orb
Shared: Incremental · Colony Sim · Idler

Melvor Idle
Shared: Casual · Idler · 2D

A Game About Feeding A Black Hole
Shared: Casual · Incremental · Idler

Fortune Mill
Shared: Idler · Incremental · Casual

Fracture Field
Shared: Idler · Incremental · Casual

Glass Masquerade
Shared: Casual · Relaxing · Atmospheric

Plantera
Shared: Idler · Incremental · Point & Click

Tiny Pasture
Shared: Idler · Casual · Incremental

Incredicer
Shared: Casual · Idler · Incremental

Factory Town Idle
Shared: Idler · Incremental · Colony Sim

Idle Champions of the Forgotten Realms
Shared: Idler · Incremental · Casual

Chill with You : Lo-Fi Story
Shared: Casual · Atmospheric · Relaxing

Loot Loop
Shared: Casual · Incremental · Idler

Game Dev Tycoon
Shared: Casual · Management · Indie

Keep on Mining! - Worlds
Shared: Casual · Incremental · Idler

Potion Craft: Alchemist Simulator
Shared: Relaxing · Casual · 2D

Human-powered spacecraft
Shared: Casual · Incremental · Idler

Bills Must Be Paid
Shared: Incremental · Casual · Idler