Games like HYPHAE
Games like HYPHAE include Creeper World 3: Arc Eternal, Defense Grid: The Awakening, FTL: Faster Than Light, Infested Planet, and Wall World. We matched them by the tags players give HYPHAE on Steam (Roguelite, Tower Defense, Indie, Sci-fi, and Nature): closest matches first, and among equally close ones the better-known games.

Creeper World 3: Arc Eternal
Shared: Tower Defense · Indie · Strategy

Defense Grid: The Awakening
Shared: Tower Defense · Sci-fi · Indie

FTL: Faster Than Light
Shared: Sci-fi · Indie · Strategy

Infested Planet
Shared: Tower Defense · Strategy · Indie

Wall World
Shared: Roguelite · Tower Defense · Strategy

Hades
Shared: Roguelite · Indie · Singleplayer

Dungeon of the ENDLESS™
Shared: Tower Defense · Indie · Strategy

Into the Breach
Shared: Indie · Strategy · Roguelite

Emberward
Shared: Tower Defense · Roguelite · Strategy

Taur
Shared: Tower Defense · Indie · Strategy

Nordhold
Shared: Tower Defense · Roguelite · Strategy

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

X-Morph: Defense
Shared: Tower Defense · Indie · Strategy

Bloons TD 6
Shared: Tower Defense · Strategy · Singleplayer

Tower Dominion
Shared: Tower Defense · Strategy · Roguelite

Tower Factory
Shared: Tower Defense · Roguelite · Strategy

Sanctum 2
Shared: Tower Defense · Sci-fi · Strategy

Anomaly Warzone Earth
Shared: Tower Defense · Indie · Strategy

Crying Suns
Shared: Roguelite · Indie · Strategy

Axon TD: Uprising - Tower Defense
Shared: Tower Defense · Roguelite · Strategy

Space Run
Shared: Tower Defense · Indie · Strategy

Warpips
Shared: Tower Defense · Strategy · Indie

Starship Troopers: Terran Command
Shared: Strategy · Sci-fi · Singleplayer

Balatro
Shared: Roguelite · Strategy · Singleplayer