Games like Humanity's Last Hope
Games like Humanity's Last Hope include Vampire Survivors, Skul: The Hero Slayer, The Binding of Isaac: Rebirth, Enter the Gungeon, and Megabonk. We matched them by the tags players give Humanity's Last Hope on Steam (Casual, Action, Shooter, Roguelike, and Action Roguelike): closest matches first, and among equally close ones the better-known games.

Vampire Survivors
Shared: Action Roguelike · Pixel Graphics · 2D

Skul: The Hero Slayer
Shared: Action · Action Roguelike · Roguelike

The Binding of Isaac: Rebirth
Shared: Roguelike · Action Roguelike · Pixel Graphics

Enter the Gungeon
Shared: Roguelike · Action Roguelike · Pixel Graphics

Megabonk
Shared: Roguelike · Action Roguelike · Action

Nuclear Throne
Shared: Roguelike · Action Roguelike · Action

Dead Cells
Shared: Roguelike · Action Roguelike · 2D

Risk of Rain (2013)
Shared: Roguelike · Action Roguelike · Action

Dungreed
Shared: Action Roguelike · Roguelike · Action

Rogue Legacy
Shared: Roguelike · Action · Action Roguelike

Dome Keeper
Shared: Action · Roguelike · Sci-fi

Rocket Rats
Shared: Casual · Action Roguelike · Pixel Graphics

Death Must Die
Shared: Action Roguelike · Action · Pixel Graphics

Broforce
Shared: Action · Pixel Graphics · 2D

Noobs Want to Live
Shared: Action · Roguelike · Casual

Hades
Shared: Action Roguelike · Action · Roguelike

Balatro
Shared: Roguelike · Pixel Graphics · Casual

Risk of Rain Returns
Shared: Action Roguelike · 2D · Action

ShellShock Live
Shared: Action · Casual · 2D

Noita
Shared: Roguelike · Pixel Graphics · 2D

Sephiria
Shared: Action Roguelike · Roguelike · Action

Risk of Rain 2
Shared: Action Roguelike · Roguelike · Action

The Binding of Isaac
Shared: Roguelike · Action Roguelike · Action

Timberman
Shared: Casual · Action · Pixel Graphics