Games like Hexisle
Games like Hexisle include Potion Craft: Alchemist Simulator, Stardew Valley, Tiny Glade, Terraria, and Disney Dreamlight Valley. We matched them by the tags players give Hexisle on Steam (Casual, Relaxing, Sandbox, 2D, and Top-Down): closest matches first, and among equally close ones the better-known games.

Potion Craft: Alchemist Simulator
Shared: Relaxing · 2D · Crafting

Stardew Valley
Shared: Relaxing · Sandbox · Casual

Tiny Glade
Shared: Relaxing · Sandbox · Casual

Terraria
Shared: Sandbox · 2D · Crafting

Disney Dreamlight Valley
Shared: Relaxing · Sandbox · Casual

Banana
Shared: Casual · 2D · Singleplayer

Starbound
Shared: Sandbox · Relaxing · Crafting

DAVE THE DIVER
Shared: Casual · Relaxing · Singleplayer

Solar 2
Shared: Casual · Sandbox · Relaxing

Keep on Mining!
Shared: Casual · Relaxing · 2D

A Game About Feeding A Black Hole
Shared: Casual · Relaxing · 2D

Townscaper
Shared: Relaxing · Sandbox · Casual

Superflight
Shared: Relaxing · Casual · Procedural Generation

Incredibox
Shared: Casual · 2D · Relaxing

Melvor Idle
Shared: Casual · 2D · Indie

Zup! S
Shared: Casual · 2D · Relaxing

To The Core
Shared: Casual · 2D · Procedural Generation

A Game About Digging A Hole
Shared: Sandbox · Mining · Procedural Generation

Click Mage
Shared: Casual · Relaxing · Fantasy

Forage Wizard
Shared: Casual · Relaxing · Sandbox

Dorfromantik
Shared: Relaxing · Casual · Sandbox

PowerWash Simulator
Shared: Casual · Relaxing · Sandbox

People Playground
Shared: Sandbox · 2D · Singleplayer

Reus
Shared: Casual · Sandbox · 2D