Games like Hexfactory
Games like Hexfactory include Dyson Sphere Program, Space Haven, Kingdoms and Castles, Timberborn, and Oxygen Not Included. We matched them by the tags players give Hexfactory on Steam (Simulation, City Builder, Colony Sim, Space Sim, and Exploration): closest matches first, and among equally close ones the better-known games.

Dyson Sphere Program
Shared: Simulation · Automation · Space

Space Haven
Shared: Colony Sim · Simulation · City Builder

Kingdoms and Castles
Shared: City Builder · Colony Sim · Simulation

Timberborn
Shared: City Builder · Colony Sim · Automation

Oxygen Not Included
Shared: Colony Sim · Simulation · Building

Settlement Survival
Shared: City Builder · Colony Sim · Simulation

Planetbase
Shared: City Builder · Colony Sim · Simulation

IXION
Shared: City Builder · Colony Sim · Simulation

Prison Architect
Shared: Simulation · Colony Sim · City Builder

Dwarf Fortress
Shared: Colony Sim · Simulation · City Builder

Manor Lords
Shared: City Builder · Simulation · Colony Sim

The Crust
Shared: Colony Sim · City Builder · Automation

Banished
Shared: City Builder · Colony Sim · Simulation

Against the Storm
Shared: Simulation · City Builder · Colony Sim

Captain of Industry
Shared: Simulation · Automation · City Builder

Kerbal Space Program
Shared: Simulation · Space Sim · Space

Cities: Skylines
Shared: Simulation · City Builder · Building

The Universim
Shared: City Builder · Colony Sim · Simulation

shapez 2 - Factory
Shared: Simulation · Automation · Building

Frostpunk
Shared: City Builder · Colony Sim · Simulation

RimWorld
Shared: Colony Sim · Simulation · Strategy

Ostriv
Shared: City Builder · Simulation · Colony Sim

Cliff Empire
Shared: City Builder · Simulation · Colony Sim

X4: Foundations
Shared: Simulation · Space Sim · Exploration