Games like Heat Signature
Games like Heat Signature include FTL: Faster Than Light, The Binding of Isaac, Crying Suns, Space Pirates and Zombies, and Skul: The Hero Slayer. We matched them by the tags players give Heat Signature on Steam (Space, Stealth, Indie, Top-Down, and Roguelike): closest matches first, and among equally close ones the better-known games.

FTL: Faster Than Light
Shared: Space · Roguelike · Indie

The Binding of Isaac
Shared: Indie · Roguelike · Top-Down

Crying Suns
Shared: Space · Indie · Strategy

Space Pirates and Zombies
Shared: Space · Indie · Action

Skul: The Hero Slayer
Shared: Indie · Action · Roguelike

No Man's Sky
Shared: Space · Sci-fi · Procedural Generation

Void War
Shared: Space · Strategy · Roguelike

Battlevoid: Harbinger
Shared: Space · Indie · Strategy

Door Kickers
Shared: Top-Down · Indie · Strategy

Reassembly
Shared: Space · Indie · Strategy

Dome Keeper
Shared: Roguelike · Action · Sci-fi

Hades
Shared: Indie · Action · Roguelike

EVERSPACE™
Shared: Space · Indie · Action

Shadow Tactics: Blades of the Shogun
Shared: Stealth · Strategy · Indie

Aliens: Dark Descent
Shared: Strategy · Action · Top-Down

Stellaris
Shared: Space · Strategy · Sci-fi

Cosmoteer: Starship Architect & Commander
Shared: Space · Indie · Sci-fi

Space Pirates And Zombies 2
Shared: Space · Indie · Action

Satellite Reign
Shared: Indie · Action · Strategy

Deliver Us The Moon
Shared: Indie · Space · Action

Baldi's Basics Plus
Shared: Stealth · Roguelike · Indie

Gunpoint
Shared: Stealth · Indie · Action

Dungeon of the ENDLESS™
Shared: Roguelike · Indie · Strategy

CRYPTARK
Shared: Indie · Action · Space