Games like Hand of Hexes
Games like Hand of Hexes include Slay the Spire, Slay the Spire 2, Balatro, Emberward, and Kingdom Rush - Tower Defense. We matched them by the tags players give Hand of Hexes on Steam (Strategy, Tower Defense, Tactical, Card Battler, and Roguelite): closest matches first, and among equally close ones the better-known games.

Slay the Spire
Shared: Card Battler · Strategy · Roguelike

Slay the Spire 2
Shared: Strategy · Roguelike · Card Battler

Balatro
Shared: Strategy · Roguelike · Roguelite

Emberward
Shared: Tower Defense · Strategy · Roguelite

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · Tactical

Tower Dominion
Shared: Strategy · Tower Defense · Tactical

Rogue Tower
Shared: Strategy · Tower Defense · Roguelike

Loop Hero
Shared: Tactical · Roguelike · Roguelite

Heretic's Fork
Shared: Tower Defense · Strategy · Deckbuilding

Dicey Dungeons
Shared: Card Battler · Roguelite · Strategy

RACCOIN: Coin Pusher Roguelike
Shared: Strategy · Roguelike · Roguelite

Dungeons & Degenerate Gamblers
Shared: Strategy · Roguelike · Card Battler

9 Kings
Shared: Strategy · Roguelike · Roguelite

Ratropolis
Shared: Strategy · Card Battler · 2D

Luck be a Landlord
Shared: Strategy · Roguelite · Deckbuilding

Across the Obelisk
Shared: Tactical · Roguelike · Card Battler

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · 2D

The King is Watching
Shared: Tower Defense · Roguelike · Strategy

Inscryption
Shared: Card Battler · Strategy · Roguelike

Kingdom Rush Origins - Tower Defense
Shared: Strategy · Tower Defense · 2D

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Card Battler · Strategy · Roguelike

Tower Tactics: Liberation
Shared: Tower Defense · Card Battler · Strategy

Bloons TD 6
Shared: Strategy · Tower Defense · 2D

Monster Train
Shared: Card Battler · Roguelite · Roguelike