Games like Guts and Syringes
Games like Guts and Syringes include Orcs Must Die! 2, Rock 'N' Roll Defense, Orcs Must Die!, Kingdom Rush - Tower Defense, and Sang-Froid - Tales of Werewolves. We matched them by the tags players give Guts and Syringes on Steam (Action, Indie, Adventure, Strategy, and Tower Defense): closest matches first, and among equally close ones the better-known games.

Orcs Must Die! 2
Shared: Action · Tower Defense · Strategy

Rock 'N' Roll Defense
Shared: Action · Strategy · Tower Defense

Orcs Must Die!
Shared: Action · Tower Defense · Strategy

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · Action

Sang-Froid - Tales of Werewolves
Shared: Action · Strategy · Indie

Deathtrap
Shared: Action · Tower Defense · Indie

Orcs Must Die! 3
Shared: Tower Defense · Strategy · Action

Space Run
Shared: Indie · Strategy · Tower Defense

Infested Planet
Shared: Action · Strategy · Indie

CARRION
Shared: Action · Gore · Indie

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Indie

X-Morph: Defense
Shared: Action · Indie · Strategy

Caster
Shared: Action · Indie · Adventure

GemCraft - Chasing Shadows
Shared: Indie · Strategy · Action

MO:Astray
Shared: Action · Indie · Adventure

Mount & Blade II: Bannerlord
Shared: Strategy · Action · Indie

Kingdom Rush 5: Alliance TD
Shared: Strategy · Tower Defense · Indie

Sanctum 2
Shared: Action · Tower Defense · Strategy

UFO 50
Shared: Indie · Action · Strategy

Hotline Miami
Shared: Action · Indie · Gore

Dungeon of the ENDLESS™
Shared: Strategy · Indie · Tower Defense

Notes of Soul
Shared: Action · Adventure · Indie

Bardbarian
Shared: Indie · Strategy · Tower Defense

My Friend Pedro
Shared: Action · Indie · Gore