Games like Geometry Defense: Infinite
Games like Geometry Defense: Infinite include Bloons TD 6, Mindustry, Age of Darkness: Final Stand, Kingdom Rush Frontiers - Tower Defense, and Oxygen Not Included. We matched them by the tags players give Geometry Defense: Infinite on Steam (Action RTS, Tower Defense, Difficult, Sandbox, and RTS): closest matches first, and among equally close ones the better-known games.

Bloons TD 6
Shared: Tower Defense · Strategy · Sandbox

Mindustry
Shared: Tower Defense · RTS · Base Building

Age of Darkness: Final Stand
Shared: Action RTS · Tower Defense · RTS

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Difficult · Strategy

Oxygen Not Included
Shared: Base Building · Sandbox · 2D

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · 2D

RimWorld
Shared: Sandbox · Strategy · Base Building

Bloons TD 5
Shared: Tower Defense · Strategy · Casual

They Are Billions
Shared: Strategy · Tower Defense · Base Building

Kingdom Rush Origins - Tower Defense
Shared: Tower Defense · Difficult · Strategy

From Glory To Goo
Shared: Tower Defense · RTS · Action RTS

Diplomacy is Not an Option
Shared: Difficult · RTS · Action RTS

Factorio
Shared: Sandbox · Base Building · Strategy

Thronefall
Shared: Tower Defense · Strategy · Action RTS

Creeper World 3: Arc Eternal
Shared: Tower Defense · Strategy · RTS

Kingdom Rush 6: Genesis TD
Shared: Tower Defense · Strategy · Action RTS

Rusted Warfare - RTS
Shared: RTS · Strategy · Base Building

Grim Nights
Shared: Tower Defense · Strategy · Base Building

Kingdom Rush Vengeance - Tower Defense
Shared: Tower Defense · Difficult · Strategy

The Riftbreaker
Shared: Tower Defense · Base Building · Sandbox

GemCraft - Frostborn Wrath
Shared: Tower Defense · Difficult · RTS

Kingdom Rush - Tower Defense
Shared: Tower Defense · Strategy · 2D

Bee Island
Shared: Tower Defense · Action RTS · Strategy

Mud and Blood
Shared: Action RTS · Difficult · Sandbox